abstract：:To verify if the entity of the peak GH responses to the GHRH+arginine (ARG) test is able to show different degree forms of GH deficiency (GHD), we linked these responses with the number of other anterior pituitary deficits. These anterior pituitary deficits were also related with IGF-I levels. To this purpose, we stud...

journal_title：Journal of endocrinological investigation

authors： Aimaretti G,Corneli G,Di Somma C,Baldelli R,Gasco V,Rovere S,Migliaretti G,Colao A,Tamburrano G,Lombardi G,Ghigo E,Camanni F

更新日期：2005-03-01 00:00:00

abstract：BACKGROUND AND AIMS:C-reactive protein (CRP) is an inflammatory marker that predicts coronary heart disease (CHD) risk. Diabetes mellitus (DM) counts as a CHD risk equivalent. We aimed to compare serum high sensitivity CRP (hs-CRP) levels in Type 2 diabetic (T2DM) men without CHD, non-diabetic CHD patients and T2DM pat...

journal_title：Journal of endocrinological investigation

authors： Bahceci M,Tuzcu A,Ogun C,Canoruc N,Iltimur K,Aslan C

更新日期：2005-02-01 00:00:00

abstract：:The unlimited availability of GH obtained by recombinant DNA technology has allowed optimization of treatment in GH-deficient (GHD) children. At the same time it has prompted a number of studies in conditions not characterized by GHD such as Turner syndrome, intrauterine growth retardation, chronic renal failure and o...

journal_title：Journal of endocrinological investigation

authors： Loche S,Casini MR,Ubertini GM,Cappa M

更新日期：2005-02-01 00:00:00

abstract：:Erectile dysfunction (ED) increases in prevalence and severity because of aging processes and related organic, iatrogenic and social problems. Decline of testosterone (T) levels is observed with age and also in illnesses with a common basis of endothelial damage. The T deficiency may lead to decreased energy, mood dep...

journal_title：Journal of endocrinological investigation

authors： Frajese GV,Pozzi F

更新日期：2005-01-01 00:00:00

abstract：:The role of androgens in human sexuality as regards the mechanism of erection and the pathogenesis of impotence is under debate. In addition, it is difficult to define the psychosocial impact of both hypogonadism and androgen replacement. However, sexual hormones largely influence mood, well-being, and quality of life...

journal_title：Journal of endocrinological investigation

authors： Carosa E,Volpe R,Martini P,Brandetti F,Di Stasi SM,Lombardo F,Salacone P,Sgrò P,Gandini L,Lenzi A,Jannini EA

更新日期：2005-01-01 00:00:00

abstract：:Effects of primary hypothyroidism (HYPO) on the male gonadal axis are controversial, with only scanty data on the gonadotroph cell response and no information on GnRH tuberoinfundibular neurons, even in animal models. HYPO has been reported to variably induce hypogonadotropic hypogonadism, a hypergonadotropic state, o...

journal_title：Journal of endocrinological investigation

authors： Toni R,Della Casa C,Castorina S,Cocchi D,Celotti F

更新日期：2005-01-01 00:00:00

abstract：:Testosterone therapy has been reported to be useful in the treatment of hypogonadism and partial androgen deficiency of the aging male (PADAM) syndrome. Testosterone administration is needed in order to maintain secondary sexual characteristics, muscle mass, bone mineral density, cognitive function and sexual drive. N...

journal_title：Journal of endocrinological investigation

authors： Volpi R,Coiro V,Chiodera P,Saccani-Jotti G,Delsignore R

更新日期：2005-01-01 00:00:00

abstract：:GH has a pivotal role in maintaining bone mass and metabolism both during childhood and in adult life. This effect depends on a complex interaction between circulating and peripherically produced GH and IGF-I. In vitro data and the use of genetically modified animals have greatly expanded the understanding of regulato...

journal_title：Journal of endocrinological investigation

authors： Bogazzi F,Cosci C,Sardella C,Martino E,Gasperi M

更新日期：2005-01-01 00:00:00

abstract：:Liver function is well maintained with increasing age. The aim of our study was to investigate if long-term moderate (

journal_title：Journal of endocrinological investigation

authors： Pinzani P,Petruzzi E,Orlando C,Malentacchi F,Petruzzi I,Pazzagli M,Masotti G

更新日期：2005-01-01 00:00:00

abstract：:Raloxifene (RLX), a selective estrogen receptor modulator (SERM), is currently indicated for the prevention and treatment of post-menopausal osteoporosis. At present, RLX is evaluated in other areas of study that include the reduction of the risk of breast cancer and cardiovascular (CV) disease in post-menopausal wome...

journal_title：Journal of endocrinological investigation

authors： Francucci CM,Romagni P,Boscaro M

更新日期：2005-01-01 00:00:00

abstract：:Signals that determine skeletal cell fate, function and apoptosis are critical to normal bone remodeling. Skeletal cells synthesize growth factors; some regulate cell replication, others regulate osteoblastic differentiation. Bone morphogenetic proteins (BMP) and Wnts induce the differentiation of mesenchymal cells to...

journal_title：Journal of endocrinological investigation

authors： Canalis E,Deregowski V,Pereira RC,Gazzerro E

更新日期：2005-01-01 00:00:00

abstract：:The somatostatin field has been a success story in terms of medicinal chemistry and drug discovery offering a variety of therapeutic opportunities. A rational medicinal chemistry approach capitalising on structure activity relationships has led to the discovery of SOM230, a novel, stable cyclohexapeptide somatostatin ...

journal_title：Journal of endocrinological investigation

authors： Lewis I,Albert R,Kneuer R,Pless J,Simeon C,Kerrad S,Hoyer D,Bruns C

更新日期：2005-01-01 00:00:00

abstract：:In acromegaly, clinical features are of the utmost importance, and biochemical confirmation is rarely difficult. However, some clinically manifest acromegalics have subtle abnormalities in GH secretion resulting in post-glucose GH nadir in the designated "normal" range with high IGF-I levels. Clinical decision may be ...

journal_title：Journal of endocrinological investigation

authors： Popovic V

更新日期：2005-01-01 00:00:00

abstract：:Somatostatin and its derivatives have been predominantly studied and succesfully used in endocrinological diseases. This article reviews the rationale of the use of somatostatin and its derivatives in ophthalmology based on current understanding of its action in the eye and summarizes previously published controlled s...

journal_title：Journal of endocrinological investigation

authors： Missotten T,Baarsma GS,Kuijpers RW,van den Born LI,van der Loos T,Croxen R,Hofland LJ,van Hagen PM

更新日期：2005-01-01 00:00:00

abstract：:The mechanisms underlying the antifertility effects of hyperprolactinemia have yet to be established in an appropriate experimental model. Hyperprolactinemia is a known side effect of fluphenazine, a broad spectrum, long-acting phenothiazine known to be dopamine type-D2 receptor antagonist. In our earlier study in adu...

journal_title：Journal of endocrinological investigation

authors： Aleem M,Choudhari J,Padwal V,Balasinor N,Parte P,Gill-Sharma MK

更新日期：2005-01-01 00:00:00

abstract：:The IGFs are ubiquitous and have pleoitropic effects. They are critical for normal growth and development, and for normal functioning of adult tissues. A liver-specific gene-deletion knockout of the IGF-I gene resulted in a mouse model with reduced circulating IGF-I levels, that led to insulin resistance due to the se...

journal_title：Journal of endocrinological investigation

authors： Yakar S,Pennisi P,Kim CH,Zhao H,Toyoshima Y,Gavrilova O,LeRoith D

更新日期：2005-01-01 00:00:00

abstract：:It is well accepted that mortality in acromegaly is increased because of cardiovascular and respiratory diseases while neoplastic complications account less to mortality. Amongst different cardiovascular complications the most frequent is biventricular hypertrophy, which occurs independently of hypertension and metabo...

journal_title：Journal of endocrinological investigation

authors： Colao A,Pivonello R,Marzullo P,Auriemma RS,De Martino MC,Ferone D,Lombardi G

更新日期：2005-01-01 00:00:00

abstract：:Obesity and insulin resistance are common features of Type 2 Diabetes. A new protein called resistin has been shown to be secreted by adipocytes in mice and to influence insulin sensitivity. The goal of the present study was to investigate the associations between one polymorphism (g-420C>G) of the human resistin gene...

journal_title：Journal of endocrinological investigation

authors： Bouchard L,Weisnagel SJ,Engert JC,Hudson TJ,Bouchard C,Vohl MC,Pérusse L

更新日期：2004-12-01 00:00:00

abstract：:The aim of this paper is to briefly review some practical aspects of the relationship between thyroid function and several disorders of the hemostatic system in terms of bleeding and thrombosis. Thrombocytopenia, acquired hemophilia, hypercoagulability, cardioembolism and other biochemical coagulative and fibrinolytic...

journal_title：Journal of endocrinological investigation

authors： Marongiu F,Cauli C,Mariotti S

更新日期：2004-12-01 00:00:00

abstract：:This study was performed to determine whether phenotypically healthy sisters of women with polycystic ovary syndrome (PCOS) have evidence of insulin resistance. We studied 54 women: 17 with PCOS, 17 sisters of these probands and 20 control women with similar age, body mass index (BMI) and waist-to-hip ratio (WHR). The...

journal_title：Journal of endocrinological investigation

authors： Diamanti-Kandarakis E,Alexandraki K,Bergiele A,Kandarakis H,Mastorakos G,Aessopos A

更新日期：2004-11-01 00:00:00

abstract：:Anorexia nervosa (AN) is a complex mental disorder presenting psychiatric and physical symptoms. Literature recognizes the role of several factors in the pathogenesis of this disorder, according to the biopsychosocial model. Many mechanisms are still partly unclear. Endocrine and metabolic alterations usually occur in...

journal_title：Journal of endocrinological investigation

authors： Abbate Daga G,Gianotti L,Mondelli V,Quartesan R,Fassino S

更新日期：2004-11-01 00:00:00

abstract：:In order to investigate the effect of gender, age and level of obesity on body composition and anaerobic power output, and to test the hypothesis that variation in body composition affects muscle power output in obesity, a cohort of 377 subjects (112 males and 265 females, aged 18-75 yr) with different levels of obesi...

journal_title：Journal of endocrinological investigation

authors： Lafortuna CL,Agosti F,Marinone PG,Marazzi N,Sartorio A

更新日期：2004-10-01 00:00:00

abstract：:In testicular descent to the scrotum, a multistep process, many anatomical and hormonal factors play a role. Cryptorchidism occurs in about 1-2% of males and may cause secondary degeneration of the testes. Animal models have shown that abnormalities, in the calcitonin gene-related peptide (CgRP) activity, could be rel...

journal_title：Journal of endocrinological investigation

authors： Zuccarello D,Morini E,Douzgou S,Ferlin A,Pizzuti A,Salpietro DC,Foresta C,Dallapiccola B

更新日期：2004-09-01 00:00:00

abstract：:It has previously been suggested that ghrelin mediates GH-independent biologic activities on the heart. We investigated the acute effects on cardiac contraction of a single iv administration of human ghrelin (in a dose of 1 microg/kg) in severe untreated GH deficient subjects. Prior to the ghrelin infusion, an echocar...

journal_title：Journal of endocrinological investigation

authors： Janssen JA,Poldermans D,Hofland LJ,Vourvouri EC,Muller AF,Bax JJ,Deghenghi R,Broglio F,Ghigo E,van der Lely AJ

更新日期：2004-07-01 00:00:00

abstract：OBJECTIVE:To assess the relationship of waist circumference and weight/height ratio with height, and their association with components of the metabolic syndrome, in Type 2 diabetic patients. DESIGN:multicenter cross-sectional survey on a cohort enrolled in a prospective observational study. SUBJECTS:13,232 patients (...

journal_title：Journal of endocrinological investigation

authors： Mannucci E,Alegiani SS,Monami M,Sarli E,Avogaro A,DAI (Diabetes and Informatics) Study Group.

更新日期：2004-06-01 00:00:00

abstract：UNLABELLED:ABSTRACT. Several data show that meal intake and nutritional status regulate circulating ghrelin concentrations in humans. Ghrelin mainly circulates in two different forms: octanoyl and des-octanoyl ghrelin. Most circulating ghrelin is des-octanoyl ghrelin which is considered inactive because it lacks endocr...

journal_title：Journal of endocrinological investigation

authors： Lucidi P,Murdolo G,Di Loreto C,Parlanti N,De Cicco A,Ranchelli A,Fatone C,Taglioni C,Fanelli C,Santeusanio F,De Feo P

更新日期：2004-05-01 00:00:00

abstract：:We describe a unique case of spontaneous resolution of hyperparathyroidism in a lady with combined parathyroid adenoma and prolactinoma, raising the possibility of underlying multiple endocrine neoplasia (MEN) 1 syndrome. We also discuss the mechanism and natural history of such spontaneous remission. ...

journal_title：Journal of endocrinological investigation

authors： Baskar V,Kamalakannan D,Singh BM,Odum J

更新日期：2004-05-01 00:00:00

abstract：:Whole-body vibration is reported to increase muscle performance, bone mineral density and stimulate the secretion of lipolytic and protein anabolic hormones, such as GH and testosterone, that might be used for the treatment of obesity. To date, as no controlled trial has examined the effects of vibration exercise on t...

journal_title：Journal of endocrinological investigation

authors： Di Loreto C,Ranchelli A,Lucidi P,Murdolo G,Parlanti N,De Cicco A,Tsarpela O,Annino G,Bosco C,Santeusanio F,Bolli GB,De Feo P

更新日期：2004-04-01 00:00:00

abstract：:We report a rare case of bilateral adrenocortical adenomas causing ACTH-independent Cushing's syndrome at different periods 9 yr apart. The subject, a 24-yr-old woman, in June 1989 had a typical Cushingoid appearance. Her baseline plasma cortisol levels did not show a diurnal rhythm and she had a very low baseline pla...

journal_title：Journal of endocrinological investigation

authors： Tung SC,Wang PW,Huang TL,Lee WC,Chen WJ

更新日期：2004-04-01 00:00:00

abstract：:Orbital fibroblasts exhibit a unique phenotype including exaggerated responses to proinflammatory cytokines. We hypothesize that the unusual susceptability of these fibroblasts to molecular cues underlies the involvement of the orbit in Graves' ophthalmopathy. A number of attributes of orbital fibroblasts are reviewed...

journal_title：Journal of endocrinological investigation

authors： Smith TJ

更新日期：2004-03-01 00:00:00

abstract：:Sleep-related breathing disorders are recognized as major health problems in obesity. They are involved in both hypertension and Type 2 diabetes, through mechanisms possibly related to increased sympathetic tone. We studied the association of habitual snoring with diabetes, hypertension, weight cycling and physical ac...

journal_title：Journal of endocrinological investigation

authors： Marchesini G,Pontiroli A,Salvioli G,Novi RF,Vitacolonna E,Taboga C,Ciccarone AM,Grossi E,QUOVADIS Study Group.

更新日期：2004-02-01 00:00:00

abstract：:Benign thyroid nodules represent a very common disorder, the management of which is still controversial. The aim of the present work was to evaluate by ultrasound examination the volume changes of thyroid nodules in post-menopausal women presenting single palpable nodular goiter of recent onset (less than 6 months fro...

journal_title：Journal of endocrinological investigation

authors： Costante G,Crocetti U,Schifino E,Ludovico O,Capula C,Nicotera M,Arturi F,Filetti S

更新日期：2004-01-01 00:00:00

abstract：:Erectile dysfunction (ED) has been defined by the National Institute of Health (NIH) as the inability to achieve and/or to maintain an erection for a sufficiently long period of time so as to permit satisfactory sexual intercourse. ED affects millions of men throughout the world and could have a negative influence on ...

journal_title：Journal of endocrinological investigation

authors： Foresta C,Caretta N,Aversa A,Bettocchi C,Corona G,Mariani S,Rossato M

更新日期：2004-01-01 00:00:00

abstract：:In 1939 Alan Turing, a major scholar in the field of mechanical computation, described a system whose computational power was beyond that of a discrete, finite state machine (Turing Machine). The composition of this system was likely the first example of what is now called an hybrid computational system. Since then, d...

journal_title：Journal of endocrinological investigation

authors： Sandri G

更新日期：2004-01-01 00:00:00

abstract：:Regulation of the hypothalamic-pituitary-thyroid (HPT) axis is dependent upon the secretion of thyrotropin-releasing hormone (TRH), a tripeptide originating in the hypothalamic paraventricular nucleus (PVN). These so-called hypophysiotropic neurons are under feedback inhibition by circulating levels of thyroid hormone...

journal_title：Journal of endocrinological investigation

authors： Lechan RM,Fekete C

更新日期：2004-01-01 00:00:00

abstract：:Sjögren's syndrome (SS) is an autoimmune epithelitis characterized by lymphocytic infiltration of exocrine glands and epithelia in multiple sites. One third of the patients present with peripheral nervous system involvement. We describe the case of a woman aged 62 affected by a peroneal nerve mononeuropathy with painf...

journal_title：Journal of endocrinological investigation

authors： Pavesi G,Cattaneo L,Chierici E,Marbini A,Sasso E,Mancia D

更新日期：2004-01-01 00:00:00

abstract：:The aim of the study was to assess iodine status in over 3800 young male subjects aged 18, living in 6 different provinces of Piemonte and in Aosta Valley, Italy. A cross-sectional study on 3837 young male subjects undergoing medical evaluation preliminary to military enrolment was performed. Spot urine samples were o...

journal_title：Journal of endocrinological investigation

authors： Fonzo D,Germano L,Gallone G,Migliardi M

更新日期：2003-12-01 00:00:00

abstract：:Peroxisome proliferator activated receptor (PPAR)gamma plays a pivotal role in regulating adipocyte differentiation and metabolism, but also has an antiproliferative effect in several tissues, including colonic mucosa, where it is highly expressed. Loss-of-function mutations have been reported in about 10% of sporadic...

journal_title：Journal of endocrinological investigation

authors： Bogazzi F,Ultimieri F,Raggi F,Russo D,Brogioni S,Cosci C,Gasperi M,Costa A,Viacava P,Mosca F,Bartalena L,Martino E

更新日期：2003-11-01 00:00:00

abstract：:Our study previously showed that estrogen and progesterone stimulated the production of matrix metalloproteinase-14 [MMP-14, or also named membrane type matrix metalloproteinses-1 (MT1-MMP)] in osteoblastic cells. MMP-14 was implied to regulate the function of osteoblasts by degrading bone matrix or growth factors, bu...

journal_title：Journal of endocrinological investigation

authors： Luo XH,Liao EY,Liao HJ,Jin Y,Zhou HD,Huang G

更新日期：2003-11-01 00:00:00

abstract：:TSH has been incriminated in Graves' disease for increasing the production of antibodies against TSH receptor (TRAb). It has been, therefore, suggested that T4 administration after successful antithyroid drug (ATD) treatment may indirectly decrease the production of TRAb and, therefore, the frequency of recurrence of ...

journal_title：Journal of endocrinological investigation

authors： Mastorakos G,Doufas AG,Mantzos E,Mantzos J,Koutras DA

更新日期：2003-10-01 00:00:00